Beyond autism: a baby siblings research consortium study of high-risk children at three years of age.

ABSTRACT:

Objective

First-degree relatives of persons with an autism spectrum disorder (ASD) are at increased risk for ASD-related characteristics. As little is known about the early expression of these characteristics, this study characterizes the non-ASD outcomes of 3-year-old high-risk (HR) siblings of children with ASD.

Method

Two groups of children without ASD participated: 507 HR siblings and 324 low-risk (LR) control subjects (no known relatives with ASD). Children were enrolled at a mean age of 8 months, and outcomes were assessed at 3 years. Outcome measures were Autism Diagnostic Observation Schedule (ADOS) calibrated severity scores, and Mullen Verbal and Non-Verbal Developmental Quotients (DQ).

Results

At 3 years, HR siblings without an ASD outcome exhibited higher

SUBMITTER: Messinger D 

PROVIDER: S-EPMC3625370 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature