Genetics and outcomes after traumatic brain injury (TBI): what do we know about pediatric TBI?

ABSTRACT: Human genetic association studies in individuals with traumatic brain injury (TBI) have increased rapidly over the past few years. Recently, several review articles evaluated the association of genetics with outcomes after TBI. However, almost all of the articles discussed in these reviews focused on adult TBI. The primary objective of this review is to gain a better understanding of which genes and/or genetic polymorphisms have been evaluated in pediatric TBI. Our initial search identified 113 articles. After review of these articles only 5 genetic association studies specific to pediatric TBI were identified. All five of these studies evaluated the apolipoprotein (APOE) gene. The study design and methods of these identified papers will be discussed. An additional search was then performe

SUBMITTER: Kurowski B 

PROVIDER: S-EPMC3625371 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature