Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus.

ABSTRACT: Diseases such as type 2 diabetes (T2D) result from environmental and genetic factors, and risk varies considerably in the population. T2D-related genetic loci discovered to date explain only a small portion of the T2D heritability. Some heritability may be due to gene-environment interactions. However, documenting these interactions has been difficult due to low availability of concurrent genetic and environmental measures, selection bias, and challenges in controlling for multiple hypothesis testing. Through genome-wide association studies (GWAS), investigators have identified over 90 single nucleotide polymorphisms (SNPs) associated to T2D. Using a method analogous to GWAS [environment-wide association study (EWAS)], we found five environmental factors associated with the disease. By foc

SUBMITTER: Patel CJ 

PROVIDER: S-EPMC3625410 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature