Nonlinear blood pressure effects on cognition in old age: separating between-person and within-person associations.

ABSTRACT: Midlife hypertension is associated with increased risk of cognitive impairment in later life. The association between blood pressure (BP) in older ages and cognition is less clear. In this study we provide estimates of between-person and within-person associations of BP and cognition in a population-based sample (N = 382) followed from age 70 across 12 occasions over 30 years. Between-person associations refer to how individual differences in BP relates to individual differences in cognition. Within-person associations refer to how individual and time specific changes in BP relate to variation in cognition. Hierarchical linear models were fitted to data from three cognitive measurements (verbal ability, spatial ability, and perceptual speed) while accounting for demographic and health-rela

SUBMITTER: Thorvaldsson V 

PROVIDER: S-EPMC3625422 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature