ATP release after partial hepatectomy regulates liver regeneration in the rat.

ABSTRACT:

Background & aims

Paracrine interactions are critical to liver physiology, particularly during regeneration, although physiological involvement of extracellular ATP, a crucial intercellular messenger, remains unclear. The physiological release of ATP into extracellular milieu and its impact on regeneration after partial hepatectomy were investigated in this study.

Methods

Hepatic ATP release after hepatectomy was examined in the rat and in human living donors for liver transplantation. Quinacrine was used for in vivo staining of ATP-enriched compartments in rat liver sections and isolated hepatocytes. Rats were treated with an antagonist for purinergic receptors (Phosphate-6-azo(benzene-2,4-disulfonic acid), PPADS), and liver regeneration after hepatectomy was analyzed.

R

SUBMITTER: Gonzales E 

PROVIDER: S-EPMC3625734 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature