Angiotensin-converting enzyme inhibitor use by older adults is associated with greater functional responses to exercise.

ABSTRACT:

Objectives

To assess the association between angiotensin converting enzyme inhibitors (ACEis) and improvements in the physical function of older adults in response to chronic exercise training.

Design

Secondary analysis of the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study, a multisite randomized clinical trial to evaluate the effects of chronic exercise on the physical function of older adults at risk for mobility disability.

Setting

Four academic research centers within the United States.

Participants

Four hundred twenty-four individuals aged 70 to 89 with mild to moderate functional impairments categorized for this analysis as ACEi users, users of other antihypertensive drugs, or antihypertensive nonusers.

Intervention

A 12-m

SUBMITTER: Buford TW 

PROVIDER: S-EPMC3625953 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature