Ontology highlight
ABSTRACT:
SUBMITTER: Xu K
PROVIDER: S-EPMC3625962 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20121201 6113
Epigenetic regulators represent a promising new class of therapeutic targets for cancer. Enhancer of zeste homolog 2 (EZH2), a subunit of Polycomb repressive complex 2 (PRC2), silences gene expression via its histone methyltransferase activity. We found that the oncogenic function of EZH2 in cells of castration-resistant prostate cancer is independent of its role as a transcriptional repressor. Instead, it involves the ability of EZH2 to act as a coactivator for critical transcription factors in ...[more]