Drug-related mutational patterns in hepatitis B virus (HBV) reverse transcriptase proteins from Iranian treatment-naive chronic HBV patients.

ABSTRACT:

Background

Immunomodulators and Nucleotide analogues have been used globally for the dealing of chronic hepatitis B virus (HBV) infection. However, the development of drug resistance is a major limitation to their long-term effectiveness.

Objectives

The aim of this study was to characterize the hepatitis B virus reverse transcriptase (RT) protein variations among Iranian chronic HBV carriers who did not receive any antiviral treatments.

Materials and methods

Hepatitis B virus partial RT genes from 325 chronic in active carrier patients were amplified and directly sequenced. Nucleotide/amino acid substitutions were identified compared to the sequences obtained from the database.

Results

All strains belonging to genotype D.365 amino-acid substitutions were found.

SUBMITTER: Mahabadi M 

PROVIDER: S-EPMC3626233 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature