[18F]-FDG uptake dose-response correlates with radiation pneumonitis in lung cancer patients.

ABSTRACT:

Purpose

To quantify the post-radiotherapy 2-[(18)F]-fluoro-2-deoxyglucose (FDG) pulmonary uptake dose-response in lung cancer patients and determine its relationship with radiation pneumonitis symptoms.

Methods and materials

The data from 24 patients treated for lung cancer with thoracic radiotherapy who received restaging PET/CT imaging between 4 and 12 weeks after radiotherapy completion were evaluated. Their radiation dose distribution was registered with the post-treatment restaging PET/CT. Using histogram analysis, the voxel average FDG-PET uptake vs. radiation dose was obtained for each case and linear regression was performed. The resulting slope, the pulmonary metabolic radiation response (PMRR), was used to characterize the dose-response. The Common Toxicity Criteri

SUBMITTER: McCurdy MR 

PROVIDER: S-EPMC3626502 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature