Genetic determinants of macular pigments in women of the Carotenoids in Age-Related Eye Disease Study.

ABSTRACT:

Purpose

To investigate genetic determinants of macular pigment optical density in women from the Carotenoids in Age-Related Eye Disease Study (CAREDS), an ancillary study of the Women's Health Initiative Observational Study.

Methods

1585 of 2005 CAREDS participants had macular pigment optical density (MPOD) measured noninvasively using customized heterochromatic flicker photometry and blood samples genotyped for 440 single nucleotide polymorphisms (SNPs) in 26 candidate genes related to absorption, transport, binding, and cleavage of carotenoids directly, or via lipid transport. SNPs were individually tested for associations with MPOD using least-squares linear regression.

Results

Twenty-one SNPs from 11 genes were associated with MPOD (P ≤ 0.05) after adjusting for d

SUBMITTER: Meyers KJ 

PROVIDER: S-EPMC3626525 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature