Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer.

ABSTRACT:

Background

Ultraconserved regions (UCR) are genomic segments of more than 200 base pairs that are evolutionarily conserved among mammalian species. They are thought to have functions as transcriptional enhancers and regulators of alternative splicing. Recently, it was shown that numerous RNAs are transcribed from these regions. These UCR-encoded transcripts (ucRNAs) were found to be expressed in a tissue- and disease-specific manner and may interfere with the function of other RNAs through RNA: RNA interactions. We hypothesized that ucRNAs have unidentified roles in the pathogenesis of human prostate cancer. In a pilot study, we examined ucRNA expression profiles in human prostate tumors.

Methods

Using a custom microarray with 962 probesets representing sense and antisense s

SUBMITTER: Hudson RS 

PROVIDER: S-EPMC3626580 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature