Species and condition specific adaptation of the transcriptional landscapes in Candida albicans and Candida dubliniensis.

ABSTRACT:

Background

Although Candida albicans and Candida dubliniensis are most closely related, both species behave significantly different with respect to morphogenesis and virulence. In order to gain further insight into the divergent routes for morphogenetic adaptation in both species, we investigated qualitative along with quantitative differences in the transcriptomes of both organisms by cDNA deep sequencing.

Results

Following genome-associated assembly of sequence reads we were able to generate experimentally verified databases containing 6016 and 5972 genes for C. albicans and C. dubliniensis, respectively. About 95% of the transcriptionally active regions (TARs) contain open reading frames while the remaining TARs most likely represent non-coding RNAs. Comparison of our ann

SUBMITTER: Grumaz C 

PROVIDER: S-EPMC3626586 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature