Analysis of copy number variations in the sheep genome using 50K SNP BeadChip array.

ABSTRACT:

Background

In recent years, genome-wide association studies have successfully uncovered single-nucleotide polymorphisms (SNPs) associated with complex traits such as diseases and quantitative phenotypes. These variations account for a small proportion of heritability. With the development of high throughput techniques, abundant submicroscopic structural variations have been found in organisms, of which the main variations are copy number variations (CNVs). Therefore, CNVs are increasingly recognized as an important and abundant source of genetic variation and phenotypic diversity.

Results

Analyses of CNVs in the genomes of three sheep breeds were performed using the Ovine SNP50 BeadChip array. A total of 238 CNV regions (CNVRs) were identified, including 219 losses, 13 gains

SUBMITTER: Liu J 

PROVIDER: S-EPMC3626776 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature