Menopausal hormone therapy and risk of cholecystectomy: a prospective study based on the French E3N cohort.

ABSTRACT:

Background

Studies in the United States and the United Kingdom have reported an increased risk of cholecystectomy among women exposed to menopausal hormone therapy, but with substantial heterogeneity between types of hormone treatments. We evaluated the risk of cholecystectomy associated with different regimens of menopausal hormone therapy in a large prospective cohort study.

Methods

Between 1992 and 2008, 70 928 menopausal women from the French E3N study cohort were sent questionnaires assessing their use of menopausal hormone therapy, medical history and lifestyle characteristics. The primary outcome was cholecystectomy. We analyzed the risk of cholecystectomy associated with use of menopausal hormone therapy using Cox proportional models, with age as time-scale.

Resul

SUBMITTER: Racine A 

PROVIDER: S-EPMC3626807 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature