Effect of prucalopride on the pharmacokinetics of oral contraceptives in healthy women.

ABSTRACT:

Background

Prucalopride is a selective, high-affinity, 5-hydroxytryptamine 4 (5-HT4) receptor agonist, which is approved for the symptomatic treatment of chronic constipation in women in whom laxatives fail to provide adequate relief. Women of childbearing potential, many of whom will be using oral contraceptives, comprise a large proportion of patients seeking medical therapy for constipation.

Objective

The aim of this study was to evaluate the effect of prucalopride on the absorption and steady-state pharmacokinetics of oral contraceptives in healthy women.

Methods

Sixteen women (aged 18-45 years) were enrolled in this open-label, two-way crossover trial (ClinicalTrials.gov identifier: NCT01036893) and given two 5-day treatments with a once-daily oral contraceptive

SUBMITTER: Van de Velde V 

PROVIDER: S-EPMC3627014 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature