Pharmacokinetics of coadministration of guanfacine extended release and methylphenidate extended release.

ABSTRACT:

Background

α2-Adrenoceptor agonists are used adjunctively to psychostimulants in treating attention-deficit/hyperactivity disorder (ADHD) when psychostimulants alone do not sufficiently reduce symptoms. However, data on the pharmacokinetic profiles and safety of combination treatments in ADHD are needed.

Objective

The primary objective of this study was to evaluate the pharmacokinetic profiles of guanfacine extended release (GXR) and methylphenidate hydrochloride (MPH) extended release, alone and in combination.

Study design

This was an open-label, randomized, three-period crossover, drug-drug interaction study.

Setting

The study was conducted at a single clinical research center.

Participants

Thirty-eight healthy adults were randomized in this study.

SUBMITTER: Roesch B 

PROVIDER: S-EPMC3627016 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature