Structure-function relationships in osteoarthritic human hip joint articular cartilage.

ABSTRACT:

Objectives

It is currently poorly known how different structural and compositional components in human articular cartilage are related to their specific functional properties at different stages of osteoarthritis (OA). The objective of this study was to characterize the structure-function relationships of articular cartilage obtained from osteoarthritic human hip joints.

Methods

Articular cartilage samples with their subchondral bone (n = 15) were harvested during hip replacement surgeries from human femoral necks. Stress-relaxation tests, Mankin scoring, spectroscopic and microscopic methods were used to determine the biomechanical properties, OA grade, and the composition and structure of the samples. In order to obtain the mechanical material parameters for the samples, a

SUBMITTER: Makela JT 

PROVIDER: S-EPMC3627049 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature