Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro.

ABSTRACT: The basolateral amygdala (BLA) has a fundamental role in affective processing. In vivo studies have revealed rhythmic population activity of a similar type to that seen in the hippocampus and cortical areas during learning tasks. The amygdala contains densely interconnected networks of inhibitory interneurons similar to those responsible for fast network activity generation in the hippocampus and other cortical structures. Here we report that neuronal networks of the BLA in isolation generate persistent, gamma frequency (30-80 Hz) oscillations upon kainate receptor activation with kainic acid. We show that, like other cortical structures, BLA oscillations are completely dependent upon γ-aminobutyric acid (GABA)ergic inhibition. GABA(A) receptor blockade abolished all oscillations, and the

SUBMITTER: Randall FE 

PROVIDER: S-EPMC3627304 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature