BLOOD TRIGGERED RAPID RELEASE POROUS NANOCAPSULES.

ABSTRACT: Rapid-release drug delivery systems present a new paradigm in emergency care treatments. Such systems combine a long shelf life with the ability to provide a significant dose of the drug to the bloodstream in the shortest period of time. Until now, development of delivery formulations has concentrated on slow release systems to ensure a steady concentration of the drug. To address the need for quick release system, we created hollow polyacrylate nanocapsules with nanometer-thin porous walls. Burst release occurs upon interaction with blood components that leads to escape of the cargo. The likely mechanism of release involves a conformational change of the polymer shell caused by binding albumin. To demonstrate this concept, a near-infrared fluorescent dye indocyanine green (ICG) was incorp

SUBMITTER: Gustafson TP 

PROVIDER: S-EPMC3627417 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature