Allogeneic hematopoietic stem-cell transplantation for sickle cell disease.

ABSTRACT:

Background

Myeloablative allogeneic hematopoietic stem-cell transplantation is curative in children with sickle cell disease, but in adults the procedure is unduly toxic. Graft rejection and graft-versus-host disease (GVHD) are additional barriers to its success. We performed nonmyeloablative stem-cell transplantation in adults with sickle cell disease.

Methods

Ten adults (age range, 16 to 45 years) with severe sickle cell disease underwent nonmyeloablative transplantation with CD34+ peripheral-blood stem cells, mobilized by granulocyte colony-stimulating factor (G-CSF), which were obtained from HLA-matched siblings. The patients received 300 cGy of total-body irradiation plus alemtuzumab before transplantation, and sirolimus was administered afterward.

Results

All 10

SUBMITTER: Hsieh MM 

PROVIDER: S-EPMC3627532 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature