A common deletion in the APOBEC3 genes and breast cancer risk.

ABSTRACT:

Background

Genome-wide association studies (GWASs) have identified multiple genetic susceptibility loci for breast cancer. However, these loci explain only a small fraction of the heritability. Very few studies have evaluated copy number variation (CNV), another important source of human genetic variation, in relation to breast cancer risk.

Methods

We conducted a CNV GWAS in 2623 breast cancer patients and 1946 control subjects using data from Affymetrix SNP Array 6.0 (stage 1). We then replicated the most promising CNV using real-time quantitative polymerase chain reaction (qPCR) in an independent set of 4254 case patients and 4387 control subjects (stage 2). All subjects were recruited from population-based studies conducted among Chinese women in Shanghai.

Results

SUBMITTER: Long J 

PROVIDER: S-EPMC3627644 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature