General olfactory sensitivity database (GOSdb): candidate genes and their genomic variations.

ABSTRACT: Genetic variations in olfactory receptors likely contribute to the diversity of odorant-specific sensitivity phenotypes. Our working hypothesis is that genetic variations in auxiliary olfactory genes, including those mediating transduction and sensory neuronal development, may constitute the genetic basis for general olfactory sensitivity (GOS) and congenital general anosmia (CGA). We thus performed a systematic exploration for auxiliary olfactory genes and their documented variation. This included a literature survey, seeking relevant functional in vitro studies, mouse gene knockouts and human disorders with olfactory phenotypes, as well as data mining in published transcriptome and proteome data for genes expressed in olfactory tissues. In addition, we performed next-generation transcrip

SUBMITTER: Keydar I 

PROVIDER: S-EPMC3627721 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature