Urinary cystatin C and acute kidney injury after cardiac surgery.

ABSTRACT:

Background

Acute kidney injury (AKI) is common after cardiac surgery and is associated with adverse patient outcomes. Urinary cystatin C (CysC) level is a biomarker of proximal tubule function and may increase earlier in AKI than serum creatinine level.

Study design

Prospective cohort study.

Settings & participants

The TRIBE AKI (Translational Research Investigating Biomarker Endpoints in AKI) Consortium prospectively enrolled 1,203 adults and 299 children and adolescents at 8 institutions in 2007-2009.

Index test

Urinary CysC (in milligrams per liter) within the first 12 hours after surgery.

Outcome

Serum creatinine-based AKI was defined as AKI Network stage 1 (mild AKI) and doubling of serum creatinine from the preoperative value or need for dialysis d

SUBMITTER: Koyner JL 

PROVIDER: S-EPMC3627833 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature