Ontology highlight
ABSTRACT:
SUBMITTER: Goel HL
PROVIDER: S-EPMC3628099 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Goel Hira Lal HL Pursell Bryan B Chang Cheng C Shaw Leslie M LM Mao Junhao J Simin Karl K Kumar Prashant P Vander Kooi Craig W CW Shultz Leonard D LD Greiner Dale L DL Norum Jens Henrik JH Toftgard Rune R Kuperwasser Charlotte C Mercurio Arthur M AM
EMBO molecular medicine 20130221 4
The characterization of cells with tumour initiating potential is significant for advancing our understanding of cancer and improving therapy. Aggressive, triple-negative breast cancers (TNBCs) are enriched for tumour-initiating cells (TICs). We investigated that hypothesis that VEGF receptors expressed on TNBC cells mediate autocrine signalling that contributes to tumour initiation. We discovered the VEGF receptor neuropilin-2 (NRP2) is expressed preferentially on TICs, involved in the genesis ...[more]