Genetic association of FKBP5 and CRHR1 with cortisol response to acute psychosocial stress in healthy adults.

ABSTRACT:

Rationale

Chronic dysregulation of hypothalamus-pituitary-adrenal (HPA) axis activity is related to several neuropsychiatric disorders. Studies suggest that cortisol response to stress has a strong genetic etiology, and that FK506 binding protein 5 (FKBP5) and G-protein coupled type-I CRH receptor (CRHR1) are key proteins regulating response. Variations in the genes encoding these proteins, FKBP5 and CRHR1, have been associated with several neuropsychiatric disorders.

Objectives

We examined variation in these genes in relation to cortisol response to psychological stress in one of the largest Trier Social Stress Test (TSST) cohorts yet examined.

Methods

A total of 368 healthy, young adults underwent the TSST. Salivary cortisol was measured at multiple time points befo

SUBMITTER: Mahon PB 

PROVIDER: S-EPMC3628278 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature