Urinary Peptide patterns in native kidneys and kidney allografts.

ABSTRACT:

Background

The use of biopsies to determine kidney health after kidney transplantation is an invasive procedure with some risk to the patient. Consequently, a noninvasive test for transplanted kidney health would provide a significant advantage over current clinical practice.

Methods

Urines from kidney donors before nephrectomy, pretransplant patients with native kidney disease, and posttransplant kidney recipients were examined for protein biomarkers to diagnose or prognose kidney disease. Proteins were extracted by C4 reverse phase affinity and analyzed by matrix assisted laser desorption/ionization time-of-flight mass spectrometry.

Results

Urine from individuals with healthy kidneys showed few components other than two ubiquitous saposin B glycoisoforms. Patients w

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC3628615 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature