Apolipoprotein E ε4 allele interacts with sex and cognitive status to influence all-cause and cause-specific mortality in U.S. older adults.

ABSTRACT:

Objectives

To confirm associations of apolipoprotein E (ApoE) ε4 carrier status, sex, and time-dependent cognitive status with mortality risk and to investigate these joint effects of these associations in a cohort of community-dwelling U.S. adults.

Design

Prospective cohort study.

Setting

The Baltimore Longitudinal Study of Aging (BLSA).

Participants

Of 3,047 BLSA participants aged 17 to 98 at first visit (60.1% male), 1,704 with complete ApoE genotype data were included, of whom 1,461 aged 50 and older with one or more visits were eligible.

Measurements

Time to death from all, cardiovascular, and noncardiovascular causes.

Results

Probability of survival was lower for ApoE ε4 carriers, particularly those who were older. A Cox proportional hazards

SUBMITTER: Beydoun MA 

PROVIDER: S-EPMC3628727 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature