Genome-wide analysis of alternative splicing during dendritic cell response to a bacterial challenge.

ABSTRACT: The immune system relies on the plasticity of its components to produce appropriate responses to frequent environmental challenges. Dendritic cells (DCs) are critical initiators of innate immunity and orchestrate the later and more specific adaptive immunity. The generation of diversity in transcriptional programs is central for effective immune responses. Alternative splicing is widely considered a key generator of transcriptional and proteomic complexity, but its role has been rarely addressed systematically in immune cells. Here we used splicing-sensitive arrays to assess genome-wide gene- and exon-level expression profiles in human DCs in response to a bacterial challenge. We find widespread alternative splicing events and splicing factor transcriptional signatures induced by an E. col

SUBMITTER: Rodrigues R 

PROVIDER: S-EPMC3629138 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature