Unknown

Dataset Information

0

Association between polymorphism of the vitamin D metabolism gene CYP27B1 and HLA-B27-associated uveitis. Is a state of relative immunodeficiency pathogenic in HLA B27-positive uveitis?


ABSTRACT:

Objective

Polymorphisms of the vitamin D metabolism gene CYP27B1 showed associations with multiple autoimmune diseases. The aim of this study was to investigate a possible association between the rs703842 A>G polymorphism of the CYP27B1 gene and HLA-B27-associated uveitis.

Design

One hundred fifty-nine patients with HLA-B27-associated uveitis, 138 HLA-B27-negative controls and 100 HLA-B27-positive controls were recruited for this retrospective case-control study. Main outcome parameters were genotype distribution and allelic frequencies determined by polymerase chain reaction.

Results

Carriers of the rs703842G allele were found significantly more often in patients with HLA-B27-associated uveitis than in HLA-B27-positive controls (p = 0.03). Between patients and HLA-B27-negative controls no significant difference in the genotype distribution of the rs703842 A>G polymorphism was found (p = 0.97).

Conclusions

Our data suggest that the rs703842 A>G polymorphism may play a role in HLA-B27-associated uveitis.

SUBMITTER: Steinwender G 

PROVIDER: S-EPMC3629157 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

altmetric image

Publications

Association between polymorphism of the vitamin D metabolism gene CYP27B1 and HLA-B27-associated uveitis. Is a state of relative immunodeficiency pathogenic in HLA B27-positive uveitis?

Steinwender Gernot G   Lindner Ewald E   Weger Martin M   Plainer Sophie S   Renner Wilfried W   Ardjomand Navid N   El-Shabrawi Yosuf Y  

PloS one 20130417 4


<h4>Objective</h4>Polymorphisms of the vitamin D metabolism gene CYP27B1 showed associations with multiple autoimmune diseases. The aim of this study was to investigate a possible association between the rs703842 A>G polymorphism of the CYP27B1 gene and HLA-B27-associated uveitis.<h4>Design</h4>One hundred fifty-nine patients with HLA-B27-associated uveitis, 138 HLA-B27-negative controls and 100 HLA-B27-positive controls were recruited for this retrospective case-control study. Main outcome para  ...[more]

Similar Datasets

| S-EPMC11518694 | biostudies-literature
| S-EPMC8594918 | biostudies-literature
2021-06-25 | GSE178833 | GEO
| PRJEB55787 | ENA
| S-EPMC4498996 | biostudies-literature
| S-EPMC3083239 | biostudies-literature
| S-EPMC7247201 | biostudies-literature
| S-EPMC4725670 | biostudies-other
2012-05-31 | E-GEOD-37588 | biostudies-arrayexpress
2012-06-01 | GSE37588 | GEO