Transcriptome profiling of the murine testis during the first wave of spermatogenesis.

ABSTRACT: Correct gene expression patterns form the basis for male germ cell differentiation and male fertility. Although previous studies have elucidated the importance of testis specific gene expression, the exact transcripts and comprehensive gene expression patterns remain unknown. Large scale sequencing techniques have enabled cost effective analysis of gene expression and isoform studies. Using the SOLiD 4 next-generation sequencing platform we have investigated the gene expression patterns at five different time points during the first wave on murine spermatogenesis. Our results highlight the upregulation of spermatogenesis related biological processes and associated cellular components. Elucidation of differential gene expression at important time points during the sperm development emphasiz

SUBMITTER: Laiho A 

PROVIDER: S-EPMC3629203 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature