AIB1 predicts bladder cancer outcome and promotes bladder cancer cell proliferation through AKT and E2F1.

ABSTRACT:

Background

We previously demonstrated that AIB1 overexpression is an independent molecular marker for shortened survival of bladder cancer (BC) patients. In this study, we characterised the role and molecular mechanisms of AIB1 in BC tumorigenicity.

Methods

AIB1 expression was measured by immunohistochemistry in non-muscle-invasive BC tissue and adjacent normal bladder tissue. In addition, the tumorigenicity of AIB1 was assessed with in vitro and in vivo functional assays.

Results

Overexpression of AIB1 was observed in tissues from 46 out of 146 patients with non-muscle-invasive BC and was an independent predictor for poor progression-free survival. Lentivirus-mediated AIB1 knockdown inhibited cell proliferation both in vitro and in vivo, whereas AIB1 overexpression p

SUBMITTER: Tong ZT 

PROVIDER: S-EPMC3629431 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature