Steroid sulphatase and oestrogen sulphotransferase in human non-small-cell lung carcinoma.

ABSTRACT:

Background

Steroid sulphatase (STS) is one of the steroid-metabolising enzymes involved in desulphating inactive steroid sulphates and oestrogen sulphotransferase (EST) sulphates active oestrogen. The roles of both STS and EST have not been examined in oestrogen-dependent non-small-cell lung cancer (NSCLC).

Methods

We evaluated the immunoreactivity of STS and EST in NSCLC cases using immunohistochemistry. The function of STS and EST was further demonstrated using NSCLC cell lines.

Results

The immunoreactivity of STS and EST was detected in 49.5% and 27.8% of NSCLC cases, respectively. The immunoreactivity of STS was significantly higher in female adenocarcinoma cases. The STS-positive NSCLCs were also significantly correlated in an inversed manner with tumour size and

SUBMITTER: Iida S 

PROVIDER: S-EPMC3629433 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature