Frontal gray matter reduction after breast cancer chemotherapy and association with executive symptoms: a replication and extension study.

ABSTRACT: Cognitive changes related to cancer and its treatment have been intensely studied, and neuroimaging has begun to demonstrate brain correlates. In the first prospective longitudinal neuroimaging study of breast cancer (BC) patients we recently reported decreased gray matter density one month after chemotherapy completion, particularly in frontal regions. These findings helped confirm a neural basis for previously reported cognitive symptoms, which most commonly involve executive and memory processes in which the frontal lobes are a critical component of underlying neural circuitry. Here we present data from an independent, larger, more demographically diverse cohort that is more generalizable to the BC population. BC patients treated with (N=27) and without (N=28) chemotherapy and matched h

SUBMITTER: McDonald BC 

PROVIDER: S-EPMC3629547 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature