Positron emission tomography imaging of fibrillar parenchymal and vascular amyloid-β in TgCRND8 mice.

ABSTRACT: Few quantitative diagnostic and monitoring, tools are available to clinicians treating patients with Alzheimer's disease. Further, many of the promising quantitative imaging tools under development lack clear specificity toward different types of Amyloid-β (Aβ) pathology such as vascular or oligomeric species. Antibodies offer an opportunity to image specific types of Aβ pathology because of their excellent specificity. In this study, we developed a method to translate a panel of anti-Aβ antibodies, which show excellent histological performance, into live animal imaging contrast agents. In the TgCRND8 mouse model of Alzheimer's disease, we tested two antibodies, M64 and M116, that target parenchyma aggregated Aβ plaques and one antibody, M31, that targets vascular Aβ. All three antibodies

SUBMITTER: McLean D 

PROVIDER: S-EPMC3629748 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature