Identification of clinical biomarkers for pre-analytical quality control of blood samples.

ABSTRACT:

Background

Pre-analytical conditions are key factors in maintaining the high quality of biospecimens. They are necessary for accurate reproducibility of experiments in the field of biomarker discovery as well as achieving optimal specificity of laboratory tests for clinical diagnosis. In research at the National Biobank of Korea, we evaluated the impact of pre-analytical conditions on the stability of biobanked blood samples by measuring biochemical analytes commonly used in clinical laboratory tests.

Methods

We measured 10 routine laboratory analytes in serum and plasma samples from healthy donors (n = 50) with a chemistry autoanalyzer (Hitachi 7600-110). The analyte measurements were made at different time courses based on delay of blood fractionation, freezing delay of fr

SUBMITTER: Kang HJ 

PROVIDER: S-EPMC3629782 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature