Innate immune network in the retina activated by optic nerve crush.

ABSTRACT:

Purpose

Innate immunity plays a role in many diseases, including glaucoma and AMD. We have used transcriptome profiling in the mouse to identify a network of genes involved in innate immunity that is present in the normal retina and that is activated by optic nerve crush (ONC).

Methods

Using a recombinant inbred (RI) mouse strain set (BXD, C57BL/6 crossed with DBA/2J mice), we generate expression datasets (Illumina WG 6.2 arrays) in the normal mouse retina and 2 days after ONC. The normal dataset is constructed from retinas from 80 mouse strains and the ONC dataset is constructed from 62 strains. These large datasets are hosted by GeneNetwork.org, along with a series of powerful bioinformatic tools.

Results

In the retina datasets, one intriguing network involves trans

SUBMITTER: Templeton JP 

PROVIDER: S-EPMC3629889 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature