Inflammation in common variable immunodeficiency is associated with a distinct CD8(+) response to cytomegalovirus.

ABSTRACT:

Background

Common variable immunodeficiency is the most common primary immunodeficiency. A subset of patients has debilitating inflammatory complications.

Objectives

We investigated the role of cytomegalovirus (CMV), and the T-cell response targeted at this virus, in this inflammatory disease.

Methods

Phenotypic and functional assays were used to profile CMV-specific T cells in patients with common variable immunodeficiency with and without inflammatory complications. Highly sensitive immunohistochemistry was used to detect CMV antigens at sites of inflammation.

Results

Cytomegalovirus was significantly associated with inflammatory disease, which occurred in 31 of 43 (72%) virus-exposed patients and 8 of 31 (26%) naive patients (P = .0001). CMV pp65-NLVPMVATV e

SUBMITTER: Marashi SM 

PROVIDER: S-EPMC3629941 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature