Estimating the similarity of alternative Affymetrix probe sets using transcriptional networks.

ABSTRACT:

Background

The usefulness of the data from Affymetrix microarray analysis depends largely on the reliability of the files describing the correspondence between probe sets, genes and transcripts. Particularly, when a gene is targeted by several probe sets, these files should give information about the similarity of each alternative probe set pair. Transcriptional networks integrate the multiple correlations that exist between all probe sets and supply much more information than a simple correlation coefficient calculated for two series of signals. In this study, we used the PSAWN (Probe Set Assignment With Networks) programme we developed to investigate whether similarity of alternative probe sets resulted in some specific properties.

Findings

PSAWNpy delivered a full textual

SUBMITTER: Bellis M 

PROVIDER: S-EPMC3630002 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature