Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice.

ABSTRACT:

Objective

Hydrogen inhalation was neuroprotective in several brain injury models. Its mechanisms are believed to be related to antioxidative stress. We investigated the potential neurovascular protective effect of hydrogen inhalation especially effect on mast cell activation in a mouse model of intracerebral hemorrhage.

Design

Controlled in vivo laboratory study.

Setting

Animal research laboratory.

Subjects

One hundred seventy-one 8-week-old male CD-1 mice were used.

Interventions

Collagenase-induced intracerebral hemorrhage model in 8-week-old male CD-1 mice was used. Hydrogen was administrated via spontaneous inhalation. The blood-brain barrier permeability and neurologic deficits were investigated at 24 and 72 hours after intracerebral hemorrhage. Mas

SUBMITTER: Manaenko A 

PROVIDER: S-EPMC3630247 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature