Copy number aberrations of genes regulating normal thymus development in thymic epithelial tumors.

ABSTRACT:

Purposes

To determine whether the deregulation of genes relevant for normal thymus development can contribute to the biology of thymic epithelial tumors (TET).

Experimental design

Using array comparative genomic hybridization, we evaluated the copy number aberrations of genes regulating thymus development. The expression of genes most commonly involved in copy number aberrations was evaluated by immunohistochemistry and correlated with patients' outcome. Correlation between FOXC1 copy number loss and gene expression was determined in a confirmation cohort. Cell lines were used to test the role of FOXC1 in tumors.

Results

Among 31 thymus development-related genes, PBX1 copy number gain and FOXC1 copy number loss were presented in 43.0% and 39.5% of the tumors, respecti

SUBMITTER: Petrini I 

PROVIDER: S-EPMC3630263 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature