Endothelial function and weight loss: comparison of low-carbohydrate and low-fat diets.

ABSTRACT:

Objective

The effect of weight loss on obesity-associated endothelial dysfunction is not clear because of conflicting data, demonstrating both improvement and no change in endothelial function after weight loss in obese subjects. A 2-year prospective study (n = 121) was conducted to examine: (1) the effect of obesity and weight loss (either a low-carbohydrate or and low-fat diet) on flow mediated vasodilatation (FMD), a measure of endothelial function.

Design and methods

Participants reduced body weight by 7.1% ± 4.4%, 8.7% ± 6.8%, 7.1% ± 7.8%, and 4.1% ± 7.7% at 3, 6, 12, and 24 months, respectively with no significant differences between the low-fat and low-carbohydrate groups.

Results

Endothelial function was inversely correlated with waist circumference, triglycer

SUBMITTER: Mohler ER 

PROVIDER: S-EPMC3630284 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature