Ontology highlight
ABSTRACT:
SUBMITTER: Pan X
PROVIDER: S-EPMC3630362 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Pan Xuan X Papasani Madhusudhan M Hao Yi Y Calamito Marco M Wei Fang F Quinn Iii William J WJ Basu Arindam A Wang Junwen J Hodawadekar Suchita S Zaprazna Kristina K Liu Huifei H Shi Yang Y Allman David D Cancro Michael M Atchison Michael L ML
The EMBO journal 20130326 8
Conditional knock-out (KO) of Polycomb Group (PcG) protein YY1 results in pro-B cell arrest and reduced immunoglobulin locus contraction needed for distal variable gene rearrangement. The mechanisms that control these crucial functions are unknown. We deleted the 25 amino-acid YY1 REPO domain necessary for YY1 PcG function, and used this mutant (YY1ΔREPO), to transduce bone marrow from YY1 conditional KO mice. While wild-type YY1 rescued B-cell development, YY1ΔREPO failed to rescue the B-cell l ...[more]