Leukotriene A4 hydrolase haplotype, diet and atherosclerosis: a twin study.

ABSTRACT:

Objective

Atherosclerosis is an inflammatory process resulting from the interaction between genetic and environmental factors. Leukotrienes are inflammatory mediators generated from arachidonic acid, and genetic polymorphisms involved in leukotriene metabolism are implicated in atherosclerosis. The objectives of this study are to examine whether genetic variants in key leukotriene enzymes are associated with atherosclerosis, and whether dietary intake of competing leukotriene substrates modifies the effect of leukotriene variants on atherosclerosis.

Methods

Atherosclerosis was assessed by common carotid intima-media thickness (IMT) using ultrasound. Sequence variants within arachidonate 5-lipoxygenase activating protein (ALOX5AP) and leukotriene A4 hydrolase (LTA4H) genes we

SUBMITTER: Zhao J 

PROVIDER: S-EPMC3630507 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature