Parental depression, maternal antidepressant use during pregnancy, and risk of autism spectrum disorders: population based case-control study.

ABSTRACT:

Objective

To study the association between parental depression and maternal antidepressant use during pregnancy with autism spectrum disorders in offspring.

Design

Population based nested case-control study.

Setting

Stockholm County, Sweden, 2001-07.

Participants

4429 cases of autism spectrum disorder (1828 with and 2601 without intellectual disability) and 43,277 age and sex matched controls in the full sample (1679 cases of autism spectrum disorder and 16,845 controls with data on maternal antidepressant use nested within a cohort (n=589,114) of young people aged 0-17 years.

Main outcome measure

A diagnosis of autism spectrum disorder, with or without intellectual disability.

Exposures

Parental depression and other characteristics prospectively

SUBMITTER: Rai D 

PROVIDER: S-EPMC3630989 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature