Effects of immunosuppression on circulating adeno-associated virus capsid-specific T cells in humans.

ABSTRACT: In humans adeno-associated virus (AAV)-mediated gene transfer is followed by expansion of AAV capsid-specific T cells, evidence of cell damage, and loss of transgene product expression, implicating immunological rejection of vector-transduced cells, which may be prevented by immunosuppressive drugs. We undertook this study to assess the effect of immunosuppression (IS) used for organ transplantation on immune responses to AAV capsid antigens. Recipients of liver or kidney transplants were tested before and 4 weeks after induction of IS in comparison with matched samples from healthy human adults and an additional cohort with comorbid conditions similar to those of the transplant patients. Our data show that transplant patients and comorbid control subjects have markedly higher frequencies

SUBMITTER: Parzych EM 

PROVIDER: S-EPMC3631016 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature