Independent contribution of A1C, systolic blood pressure, and LDL cholesterol control to risk of cardiovascular disease hospitalizations in type 2 diabetes: an observational cohort study.

ABSTRACT:

Background

Cardiovascular disease (CVD) prevention in diabetes requires broad-based treatment of dyslipidemia, hypertension, and hyperglycemia. The independent contribution of all combinations of risk factor control to CVD risk has not been evaluated.

Objective

To estimate the independent association of control of glycosylated hemoglobin (A1C), systolic blood pressure (SBP), and low-density lipoprotein cholesterol (LDL-C) with risk of cardiovascular disease hospitalization.

Design

Non-concurrent longitudinal cohort study.

Patients

The study included 26,636 patients with type 2 diabetes who were members of an integrated group model HMO with multiple A1C, SBP, and LDL-C measurements.

Main measures

Patients were followed for a mean (SD) of 5.6 (2.5) years u

SUBMITTER: Nichols GA 

PROVIDER: S-EPMC3631078 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature