Association of AMP-activated protein kinase with risk and progression of non-Hodgkin lymphoma.

ABSTRACT:

Background

Metabolic dysregulation has been identified as an "emerging hallmark" of cancer. The heterotrimeric AMP-activated protein kinase (AMPK) complex is a central regulator of the metabolic system and an important component of the mTOR pathway and the p53 axis, making it uniquely positioned to influence carcinogenesis through its canonical functions in the metabolic arena, as well as through more traditional mechanisms such as regulation of apoptosis and angiogenesis.

Methods

We conducted a population-based genetic association study to examine the impact of mutations in AMPK subunit genes on risk of non-Hodgkin lymphoma (NHL). We also analyzed public microarray data to determine the expression of AMPK in NHL cells and to assess the influence of AMPK expression on overal

SUBMITTER: Hoffman AE 

PROVIDER: S-EPMC3631103 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature