The timing hypothesis for coronary heart disease prevention with hormone therapy: past, present and future in perspective.

ABSTRACT: Over the past decade, two informative events in primary prevention of coronary heart disease (CHD) have occurred for women's health. The first concerns hormone replacement therapy (HRT) where data have come full circle from presumed harm to consistency with observational data that HRT initiation in close proximity to menopause significantly reduces CHD and overall mortality. The other concerns sex-specific efficacy of CHD primary prevention therapies where lipid-lowering and aspirin therapy have not been conclusively shown to significantly reduce CHD and, more importantly, where there is lack of evidence that either therapy reduces overall mortality in women. Cumulated data support a 'window-of-opportunity' for maximal reduction of CHD and overall mortality and minimization of risks with H

SUBMITTER: Hodis HN 

PROVIDER: S-EPMC3631510 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature