Optical coherence tomography grading reproducibility during the Comparison of Age-related Macular Degeneration Treatments Trials.

ABSTRACT:

Objective

To report reading center reproducibility during grading of Stratus optical coherence tomography (OCT) (Carl Zeiss Meditec, Dublin, CA) images obtained during the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT).

Design

Prospective, clinical trial.

Participants

Independent reading teams reevaluated 270 OCT scans randomly sampled from the first 2 years of CATT enrollment. To assess temporal drift, a cohort of 23 scans submitted during the initial portion of the CATT study was longitudinally followed with serial reproducibility analysis.

Intervention

The CATT readers performed standardized grading of OCT images. A reader team, composed of 2 independent readers and a senior reader, evaluated each scan. Grading included the CATT OCT

SUBMITTER: DeCroos FC 

PROVIDER: S-EPMC3631582 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature