Oncolytic virus therapy for glioblastoma multiforme: concepts and candidates.

ABSTRACT: Twenty years of oncolytic virus development have created a field that is driven by the potential promise of lasting impact on our cancer treatment repertoire. With the field constantly expanding-more than 20 viruses have been recognized as potential oncolytic viruses-new virus candidates continue to emerge even as established viruses reach clinical trials. They all share the defining commonalities of selective replication in tumors, subsequent tumor cell lysis, and dispersion within the tumor. Members from diverse virus classes with distinctly different biologies and host species have been identified. Of these viruses, 15 have been tested on human glioblastoma multiforme. So far, 20 clinical trials have been conducted or initiated using attenuated strains of 7 different oncolytic viruses a

SUBMITTER: Wollmann G 

PROVIDER: S-EPMC3632333 | biostudies-literature | 2012 Jan-Feb

REPOSITORIES: biostudies-literature